论文部分内容阅读
于孕期给受孕ＩＣＲ小鼠经口灌胃０，４，２０和１００ｍｇ／ｋｇ咖啡因，观察其子代的行为功能状况。结果表明：２０ｍｇ／ｋｇ剂量组（相当于人每天喝１０杯咖啡）出现了明显的仔鼠体格发育迟缓，早期反射和感觉功能障碍，以及学习记忆能力下降的行为功能改变；１００ｍｇ／ｋｇ剂量组除出现上述改变外，死胎数增多。３个剂量组均未出现胎鼠的形态异常。提示，咖啡因在不引起仔鼠形态改变的剂量下，可引起仔鼠行为功能的异常。
During pregnancy, ICR mice were orally fed with 0, 4, 20 and 100 mg / kg of caffeine, and the behavior and function of their offspring were observed. The results showed that: 20mg / kg dose group (equivalent to drinking 10 cups of coffee a day) showed obvious growth retardation, early reflex and sensory dysfunction, and learning and memory abilities of behavioral changes; 100mg / kg dose group In addition to the above changes, the number of stillbirths increased. Three dose groups did not appear morphological abnormalities of fetal rats. Tip, caffeine does not cause pups morphological changes in dose, can cause behavioral abnormalities offspring.