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目的分析正常成人前列腺外周带扩散峰度成像(DKI)相关参数与年龄相关性变化趋势。方法将67名符合纳入标准的健康志愿者按年龄分成3组:A组(15~30岁,n=26),B组(31~50岁,n=20),C组(≥51岁,n=21)。对所有志愿者行MRI常规序列扫描及DKI扫描,应用扩散峰度模型分析得出平均扩散峰度(MK)、平均扩散系数(MD)及各向异性分数(FA)值。采用配对样本t检验分析前列腺外周带左、右两侧各参数之间差异;采用方差分析(ANOVA)及LSD法对各参数在不同年龄段前列腺外周带中的差异进行比较。采用Pearson相关性分析对各参数与年龄相关性进行分析。结果 MK、MD和FA值在左、右两侧前列腺外周带之间差异无统计学意义(P>0.05);3组外周带的MK值分别为0.714±0.058、0.682±0.057、0.584±0.046;MD值分别为(1.781±0.183)、(1.937±0.234)、(2.323±0.314)μm~2/ms;FA值分别为0.207±0.033、0.183±0.016、0.154±0.026,不同年龄组外周带的MK、MD和FA值差异均有统计学意义(P<0.05);Pearson相关性分析结果表明,外周带MK值与年龄呈负相关(r=-0.811,P<0.05),FA值与年龄呈负相关(r=-0.691,P<0.05),而MD值与年龄呈正相关(r=0.785,P<0.05)。结论正常成人前列腺外周带的MK、MD和FA值与年龄相关,随年龄的增长,MK、FA值呈降低趋势,而MD值呈升高趋势。
Objective To analyze the trend of age-related changes in related parameters of diffusion-related kurtosis imaging (DKI) in the peripheral zone of prostatic glands in normal adults. Methods Sixty-seven healthy volunteers were divided into three groups according to age: group A (15-30 years old, n = 26), group B (31-50 years old, n = 20), group C n = 21). All volunteers underwent routine MRI scan and DKI scan, and averaged diffusion kurtosis (MK), average diffusion coefficient (MD) and anisotropic fraction (FA) were calculated by using diffusion kurtosis model. Paired sample t-test was used to analyze the differences between the left and right prostatic peripheral bands. ANOVA and LSD were used to compare the differences of prostatic peripheral bands in different age groups. Pearson correlation analysis of each parameter and age-related analysis. Results MK, MD and FA had no significant difference in the peripheral zone between the left and right prostate (P> 0.05). The values of MK in the peripheral zone of the three groups were 0.714 ± 0.058, 0.682 ± 0.057 and 0.584 ± 0.046, respectively. The MD values were (1.781 ± 0.183), (1.937 ± 0.234) and (2.323 ± 0.314) μm ~ 2 / ms, respectively. The FA values were 0.207 ± 0.033, 0.183 ± 0.016 and 0.164 ± 0.026, respectively. MK in different age groups (P <0.05). The results of Pearson correlation analysis showed that MK value in peripheral zone was negatively correlated with age (r = -0.811, P <0.05), while FA value was negative with age (R = -0.691, P <0.05), while the MD value was positively correlated with age (r = 0.785, P <0.05). Conclusion The MK, MD and FA values in the peripheral zone of normal adult prostate are related to age. With the increase of age, the values of MK and FA decrease and the MD increases.