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他汀类药物是羟甲基戊二酸单酰辅酶A(HMG-CoA)还原酶的抑制剂,因其显著的降脂功能而广泛应用于治疗动脉粥样硬化和心血管疾病。近年来研究发现,他汀类药物在CD4+T细胞介导的多种自身免疫性疾病中显示了免疫调节功能,可有效预防和治疗这类疾病。本文将对他汀类药物的免疫调节功能及潜在机制进行初步的探讨。
Statins are inhibitors of hydroxymethyl glutaryl coenzyme A (HMG-CoA) reductase and are widely used in the treatment of atherosclerosis and cardiovascular disease due to their significant lipid-lowering properties. Recent studies have found that statins show immunomodulatory function in a variety of autoimmune diseases mediated by CD4 + T cells and are effective in preventing and treating such diseases. This article will initially investigate the immunomodulatory function and underlying mechanisms of statins.