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目的:观察苯妥英钠对急性脑梗死患者血S-100β蛋白含量及局部脑血流量(rCBF)的影响。方法:将60例患者随机分为对照组和苯妥英钠治疗组,测定治疗前后血清S-100β蛋白的含量;选取30例行单光子发射断层扫描脑血流灌注显像,观察苯妥英钠对rCBF的影响;并观察其临床疗效。结果:经苯妥英钠治疗后,患者血清S-100β蛋白含量明显降低;rCBF明显改善;神经功能缺损评分明显降低。结论:苯妥英钠可降低急性脑梗死后的血清S-100β蛋白含量,增加rCBF,促进临床神经功能的恢复。
Objective: To observe the effect of phenytoin on blood S-100β protein and regional cerebral blood flow (rCBF) in patients with acute cerebral infarction. Methods: Sixty patients were randomly divided into control group and phenytoin treatment group. The content of S-100β protein in serum was detected before and after treatment. Thirty patients underwent single-photon emission computed tomography (CT) brain perfusion imaging. The effects of phenytoin on rCBF Influence; and observe its clinical efficacy. Results: After treatment with phenytoin sodium, the serum S-100β protein content was significantly reduced; rCBF was significantly improved; neurological deficit score was significantly lower. Conclusion: Phenytoin sodium can reduce serum S-100β protein content after acute cerebral infarction, increase rCBF, and promote the recovery of clinical neurological function.