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目的探讨肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、C反应蛋白(CRP)及D-二聚体(D-Dimer)、纤维蛋白原(Fib),在急性脑梗死(ACI)患者中的含量变化及其临床意义。方法选取84例ACI患者(小体积ACI为A组35例、中体积ACI为B组29例、大体积ACI组为C组20例)和同期63例健康体检者为对照组,检测2组TNF-α、IL-6、CRP及D-Dimer、Fib的水平,并进行比较分析。结果 ACI患者血中TNF-α、IL-6、CRP及D-Dimer、Fib 5个时间(1 d、3 d、5 d、7 d、14 d)段各组间差异具有统计学意义(P<0.01);1 d~3 d炎症因子、凝血指标均在升高,5 d~14 d逐渐下降,其中1 d~7 d各项指标与对照组比较,差异均具有统计学意义(P<0.01);A、B、C 3组比较,其中1 d~7 d C组TNF-α、IL-6、CRP及D-Dimer、Fib水平高于A、B 2组(P<0.05或P<0.01)。结论检测血清TNF-α、IL-6、CRP及D-Dimer、Fib水平对判断脑梗死患者病情具有重要的临床意义。
Objective To investigate the expression of TNF-α, IL-6, CRP, D-Dimer and fibrinogen in acute brain Changes in patients with infarction (ACI) and its clinical significance. Methods 84 cases of ACI patients (small volume ACI for the A group of 35 cases, the volume of ACI for the B group of 29 cases, the large volume of ACI group for the C group of 20 cases) and the same period in 63 healthy subjects as control group, two groups of TNF -α, IL-6, CRP and D-Dimer, Fib levels, and comparative analysis. Results There were statistically significant differences in the levels of TNF-α, IL-6, CRP, D-Dimer and Fib in 5 groups of ACI patients at 1, 3, 5, 7 and 14 days <0.01). Inflammatory factors and coagulation indexes increased from day 1 to day 3, and gradually decreased from day 5 to day 14. The differences between the indexes on day 1 and day 7 in the control group were statistically significant (P < 0.01). The levels of TNF-α, IL-6, CRP, D-Dimer and Fib in group A, B and C at 1 d to 7 d were higher than those in group A and B 2 (P <0.05 or P < 0.01). Conclusion The detection of serum TNF-α, IL-6, CRP and D-Dimer, Fib levels in judging the severity of patients with cerebral infarction has an important clinical significance.