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目的探讨中药抗病毒胶囊治疗生殖器疱疹的作用机理。方法用抗病毒胶囊治疗初发性生殖器疱疹豚鼠模型,然后对豚鼠的大脑、脊髓、宫颈、阴道进行HSV鄄2DNA荧光定量PCR检测。结果在各组动物中,4个不同部位均有病毒DNA的存在;不同部位的病毒拷贝量有差异,不同组之间相应部位比较也存在差异。经单因素方差分析,脊髓、阴道处病毒拷贝量最高,大脑、宫颈处病毒拷贝量相当;生理盐水组与其它各组比较相应部位差异均有显著性(P<0.01)。中药抗病毒胶囊组与阿昔洛韦组各处病毒拷贝量差异无显著性(P>0.05)。结论中药抗病毒胶囊治疗生殖器疱疹的作用机理可能为阻止HSV的潜伏和抑制HSV的复制增殖。
Objective To explore the mechanism of Chinese herbal antiviral capsule in the treatment of genital herpes. Methods The guinea pig model of primary genital herpes was treated with antiviral capsule, and then the brain, spinal cord, cervix, and vagina of guinea pigs were subjected to HSV 2 DNA quantitative PCR detection. RESULTS: Viral DNA was present in 4 different sites in each group of animals; the virus copies at different sites were different, and there were differences in corresponding sites between different groups. After one-way analysis of variance, viral copies were highest in the spinal cord and vagina, and virus copies were comparable in the brain and cervix; differences in the corresponding sites between the saline group and other groups were significant (P<0.01). There was no significant difference in the virus copies between the antiviral capsule group and the acyclovir group (P>0.05). Conclusion The anti-viral capsule treatment of genital herpes may play a role in preventing the latency of HSV and inhibiting the replication and proliferation of HSV.