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用三甲基胆蒽皮下诱发小鼠肉瘤，观察亚硒酸钠与维生素Ｅ对此肉瘤发生的影响。结果表明，亚硒酸钠组小鼠，延缓肉瘤发生时间，与对照组比较肉瘤发生率由５３．３％降至２７．７％，维生素Ｅ组，无降低肉瘤发生作用。亚硒酸钠与维生素Ｅ联合应用组肉瘤发生率与亚硒酸钠组相似，亚硒酸钠组能明显升高小鼠血中谷胱甘肽过氧化物酶的活性及血中硒的含量，维生素Ｅ无此作用。结果说明亚硒酸钠与维生素Ｅ虽都为抗氧化剂，并都被认为有防癌作用，但它们对本实验三甲基胆蒽皮下诱发肉瘤的作用似不相同。
A mouse sarcoma was induced subcutaneously with trimethylcholestan, and the effect of sodium selenite and vitamin E on the occurrence of this sarcoma was observed. The results showed that the mice in the selenite group delayed the occurrence of sarcomas and the incidence of sarcomas decreased from 53.3% to 27.7% compared with the control group. In the vitamin E group, there was no effect of reducing sarcoma. The incidence of sarcoma in the combination of sodium selenite and vitamin E was similar to that of sodium selenite group. Sodium selenite group could significantly increase the activity of blood glutathione peroxidase and the content of selenium in blood. Vitamin E has no such effect. The results show that although sodium selenite and vitamin E are both antioxidants, and they are all considered to have anti-cancer effects, they do not seem to have the same effect on the subcutaneous sarcoma-induced sarcoma in this experiment.