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目的研究肝硬变门静脉高压症患者血中血管活性肠肽水平的变化。方法以放射免疫分析法测定32例肝硬变门静脉高压症患者和对照组30例无肝脏和胰腺疾病的胆结石患者的门静脉、外周静脉和动脉血中的血管活性肠肽水平。结果肝硬变组与对照组血管活性肠肽水平的比较结果为:门静脉:104±41/71±19(P<0.01);外周静脉:89±24/50±18(P<0.01);动脉:86±21/46±15(P<0.01)。结论肝硬变门静脉高压症患者门静脉、外周静脉和动脉血中血管活性肠肽水平明显高于对照组。
Objective To study the changes of blood vasoactive intestinal peptide in cirrhotic patients with portal hypertension. Methods Radioimmunoassay was used to determine the levels of vasoactive intestinal peptide in portal vein, peripheral vein and arterial blood of 32 patients with cirrhosis and portal hypertension who had cirrhosis and control group without gallstone or pancreatic disease. Results The results of comparison of the levels of vasoactive intestinal peptide between cirrhosis group and control group were: portal vein: 104 ± 41/71 ± 19 (P <0.01); peripheral vein: 89 ± 24/50 ± 18 : 86 ± 21/46 ± 15 (P <0.01). Conclusions The levels of vasoactive intestinal peptide in portal vein, peripheral vein and arterial blood in cirrhotic patients with portal hypertension are significantly higher than those in control group.