当细胞内的自由基产物超出其自身的抗氧化能力时,便会产生氧化应激。糖尿病时由于葡萄糖代谢异常,自由基产生过多,导致氧化应激。急性或慢性的高血糖均可促使周围神经组织内自由基的产生,促进糖尿病神经病变的发展。动物实验和临床研究中针对氧化应激进行的抗氧化治疗,均取得了一定的疗效,提示氧化应激在糖尿病神经病变中发挥重要作用。 Oxidative stress occurs when free radicals in the cell exceed their own antioxidant capacity. Diabetes due to abnormal glucose metabolism, excessive free radicals, leading to oxidative stress. Acute or chronic hyperglycemia can promote the production of free radicals in peripheral nerve tissue and promote the development of diabetic neuropathy. Animal experiments and clinical studies on the antioxidant oxidative stress treatment, have achieved a certain effect, suggesting that oxidative stress in diabetic neuropathy play an important role.