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目的:研究胰腺癌组织中IL-8表达并探讨其临床病理意义。方法:胰腺癌手术切除标本51例经4 g/L甲醛固定后常规制作石蜡包埋切片,染色为ABC免疫组化法。结果:胰腺癌组织中IL-8阳性率及其评分明显低于低分化、无转移病例。其中分化程度、转移状况之间均有统计学差异(P<0.05)。IL-8与胰腺癌其他临床病理牲无明显关系(P>0.05)。结论:IL-8表达可能是反映胰腺癌发生、发展、生物学行为和预后的重要标记物。
Objective: To study the expression of IL-8 in pancreatic cancer and to explore the clinicopathological significance. Methods: 51 cases of pancreatic cancer resected specimens were fixed by 4 g / L formalin-fixed paraffin-embedded sections were stained by ABC immunohistochemistry. Results: The positive rate and the score of IL-8 in pancreatic cancer tissues were significantly lower than those in poorly differentiated and metastatic cases. Among them, there was a significant difference between differentiation and metastasis (P <0.05). There was no significant correlation between IL-8 and other clinicopathological features of pancreatic cancer (P> 0.05). Conclusion: IL-8 expression may be an important marker of pancreatic cancer occurrence, development, biological behavior and prognosis.