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气胸是临床上常见的一种疾病,但有些患者的治疗仍然是很困难的。文中报道了胸腹腔内注入大量稀释的纤维蛋白胶(Diluted Fibrin Glue,DFG)治疗难治性气胸的结果。 40例对胸腔闭式引流有禁忌症的气胸患者(A组)和13例肺切除后长期漏气且伴胸膜内死腔的患者(B组)作为研究对象。所有患者均接受胸膜腔内注入大量DFG治疗。A组患者的平均年龄72岁,男性39例,女性1例。左侧气胸17例,右侧气胸23例 气胸的原因有严重肺气肿、肺大泡、肺纤维化等。合并症有心肌梗死、严重糖尿病、肝硬化、肾衰、晚期癌症、肌萎缩侧索硬化、结节病以及系统性红斑狼疮等。5例患者因肺病急剧恶化正在接受机械换气。B组平均年龄60岁,全部患者为男性。DFG的用法是将纤维蛋白胶
Pneumothorax is a common clinical disease, but some patients are still very difficult to treat. The article reports the results of thoracic and abdominal cavity injection of a large number of diluted fibrin glue (Diluted Fibrin Glue, DFG) treatment of refractory pneumothorax results. Forty patients with pneumothorax contraindicated for thoracic drainage (group A) and 13 patients with long-term air leaks and pleural dead space after pneumonectomy (group B) were enrolled. All patients underwent pleural cavity infusion of large doses of DFG. The mean age of patients in group A was 72 years, 39 males and 1 females. The left pneumothorax in 17 cases, the right pneumothorax 23 cases of pneumothorax due to severe emphysema, bullae, pulmonary fibrosis and so on. Complications of myocardial infarction, severe diabetes, cirrhosis, renal failure, advanced cancer, amyotrophic lateral sclerosis, sarcoidosis and systemic lupus erythematosus. Five patients were undergoing mechanical ventilation due to a sharp deterioration in lung disease. Group B, the average age of 60 years, all patients were male. DFG’s usage is to fibrin glue