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目的 :研究电刺激小脑顶核对血管性痴呆 (vasculardementia ,VD)大鼠的治疗作用与机制。方法 :持久性双侧颈总动脉结扎造成老龄大鼠慢性前脑灌注不足 ,建立近似人类学习记忆障碍的大鼠VD模型。治疗组大鼠小脑顶核给予电刺激 ,用电脑控制穿梭箱系统检测大鼠的认知能力。结果 :慢性前脑灌注不足 2个月后大鼠学习记忆能力均下降 ,4个月后更明显 ;电刺激痴呆大鼠小脑顶核后 ,学习及记忆能力明显提高 ,学习提高更明显。结论 :电刺激小脑顶核可显著改善痴呆的大鼠的认知能力。
Objective: To investigate the therapeutic effect and mechanism of electrical stimulation of cerebellar fastigial nucleus on vascular dementia (VD) rats. Methods: Ligation of persistent bilateral common carotid arteries caused chronic anterior cerebral hypoperfusion in aged rats, establishing a rat model of VD that approximates human learning and memory impairment. The rats in the treatment group were given electrical stimulation of the cerebellar fastigial nucleus, and the rats’ cognitive ability was detected by the computer controlled shuttle box system. Results: After 2 months of chronic forebrain perfusion, the learning and memory abilities of rats decreased after 4 months, and were more obvious after 4 months. After the cerebellar fastigial nucleus was stimulated by electrical stimulation, the learning and memory abilities of dementia rats were significantly improved and learning was improved more significantly. Conclusion: Electrical stimulation of the cerebellar fastigial nucleus can significantly improve the cognitive ability of rats with dementia.