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本文以9名健康志愿者为试验对象,在空腹和进食条件下分别交叉口服环丙沙星片剂,采用二阶导数分光光度法测定尿药浓度。结果表明:进食对环丙沙星生物利用度无明显影响。空腹和进食条件48h 尿中排药量分别为47%±8%和44%±8.4%(P>0.05)。但进食条件可延缓该药的吸收速率和缓解该药的胃肠道反应。
In this paper, nine healthy volunteers as subjects, oral administration of ciprofloxacin tablets under fasting and feeding conditions, using second-derivative spectrophotometric determination of urine concentration. The results showed that: feeding on the bioavailability of ciprofloxacin no significant effect. 48h urine fasting and feeding conditions were 47% ± 8% and 44% ± 8.4% (P> 0.05). However, eating conditions can delay the drug’s absorption rate and ease the drug’s gastrointestinal response.