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Ⅶ型胶原是胶原蛋白家族中遗传上独特的一个成员,它是锚纤维的主要成分,锚纤维是皮肤基底膜粘着于其下方真皮的复合物.近来,已经克隆出Ⅶ型胶原相应的基因,对其结构的了解更进了一步.通过制定3号染色体短臂基因图谱并识别了基因内多型性标记,表明Ⅶ型胶原的位点和营养不良型大疱性表皮松解症有很强的基因连锁.此篇综述概括了Ⅶ型胶原分子遗传学方面的研究进展.
Collagen type Ⅶ is a genetically unique member of the collagen family that is the main component of the anchor fiber, a complex of the dermal basement membrane that adheres to the dermis beneath it. Recently, the corresponding gene for type Ⅶ collagen has been cloned, The understanding of its structure goes a step further by establishing a map of the short arm of chromosome 3 and identifying polymorphic markers within the gene, indicating that the site of type Ⅶ collagen and dystrophic bullous epidermolysis have a strong This review summarizes the research advances in type Ⅶ collagen molecular genetics.