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目的探讨原发性肝细胞癌(HCC)的超声造影增强表现及与分化程度的相关性。方法选取我院602例肝脏占位性病变经超声造影检查及手术或穿刺活检病理确诊为HCC中93例患者的112个病灶,记录其超声造影增强时间,分析不同分化程度肝癌的增强时相及灌注模式。结果93例(112个癌灶)中病理诊断为中低分化HCC65例(74个癌灶),高分化HCC28例(38个癌灶)。中低分化HCC组癌灶平均大小(3.99±2.08)cm,高分化HCC组癌灶平均大小(3.38±1.44)cm,两组相比差异有统计学意义(P<0.05)。中低分化HCC74灶(100%)25s内快速增强,71灶(95.9%)90s内快速退出;高分化HCC38灶(100%)25s内快速增强,22灶(57.9%)90s内快速退出,16灶(42.1%)90s后缓慢退出,不同分化程度HCC退出时间相比差异有统计学意义(P<0.05)。结论HCC超声造影增强表现与分化程度有一定相关性,退出缓慢病灶可能分化程度较高。
Objective To investigate the enhancement of contrast-enhanced ultrasound and its correlation with the degree of differentiation of primary hepatocellular carcinoma (HCC). Methods A total of 112 lesions of 93 patients with HCC were confirmed by contrast-enhanced ultrasonography and surgery or biopsy of 602 liver space-occupying lesions in our hospital. The time of contrast enhanced ultrasound (CEUS) was recorded. The enhancement phase of hepatocellular carcinoma with different degrees of differentiation Perfusion mode Results Ninety-three cases (112 lesions) were pathologically diagnosed as moderate-poorly differentiated HCC (74 lesions) and well-differentiated HCC (28 lesions). The average size of tumor in poorly differentiated HCC group was (3.99 ± 2.08) cm, and the average size of cancerous tissue in well differentiated HCC group was (3.38 ± 1.44) cm. There was significant difference between the two groups (P <0.05). In moderately poorly differentiated HCC74 foci (100%) rapidly enhanced within 25s, 71 (95.9%) flushed rapidly in 90s; well-differentiated HCC38 foci (100%) rapidly increased in 25s, 22 (57.9% The stove (42.1%) quit slowly after 90s, and there was significant difference (P <0.05) between the exit times of HCC with different degrees of differentiation. Conclusions The enhancement of contrast-enhanced ultrasound is correlated with the degree of differentiation, and the slow-moving lesion may have a higher degree of differentiation.