目的　探讨冷冻综合治疗肝癌的疗效。方法　应用 L SC- 2 0 0 0型冷冻机对 5 3例肝癌分别采取冷冻加手术切除 ;冷冻加肝动脉、门静脉置管化疗 ;冷冻加手术切除和肝动脉、门静脉置管化疗。结果　全组无手术死亡及严重并发症 ;冷冻后 1、2、3年生存率分别为 73.6 %、6 2 .5 %、5 2 .8% ,其中 12例≤ 5 mm的小肝癌分别为 91.7%、83.3%、75 %。结论　冷冻综合治疗为中晚期肝癌提供了有效的治疗途径 :切除肿瘤或 /和行肝动脉、门静脉置管化疗能够降低肝癌术后的复发 Objective To investigate the curative effect of comprehensive treatment of liver cancer by freezing. Methods Five hundred fifty cases of HCC were removed by cryosurgery and surgical excision with L SC-200 type freezer. The animals were treated by freezing and hepatic artery and portal vein catheterization, and were treated by cryosurgery combined with resection and hepatic artery and portal vein catheterization chemotherapy. Results There was no operative mortality and serious complications in the whole group. The 1, 2, 3 year survival rates were 73.6%, 62.5% and 52.2% respectively after freezing, of which 12 cases of small hepatocellular carcinoma ≤ 5 mm were 91.7% %, 83.3%, 75%. Conclusion The integrated treatment of frozen provides an effective treatment for advanced liver cancer: resection of the tumor or / and the hepatic artery, portal vein catheterization chemotherapy can reduce the recurrence of postoperative liver cancer