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选取昆明种小鼠40只,雌雄各半,随机分成7,8-氧化苯乙烯(SO)低(125 mg/kg)、中(250 mg/kg)、高(500 mg/kg)3个剂量组和对照组。空腹灌胃染毒,24 h后测定血液、肝脏、脑、肾脏组织的丙二醛(MDA)含量及超氧化物歧化酶(SOD)活性。SO中、高剂量染毒组小鼠肝脏SOD活性下降,与对照组比较差异有统计学意义(P<0.05),各剂量染毒组脑组织SOD活性增高,MDA含量下降,与对照组比较差异有统计学意义(P<0.05,P<0.01);提示7,8-氧化苯乙烯可致脑和肝组织的氧化损伤。
Forty Kunming mice were randomly divided into three groups: male, female and male mice. The mice were randomly divided into 3 dosages (250 mg / kg), high (500 mg / kg) Group and control group. After 24 hours, the content of malondialdehyde (MDA) and the activity of superoxide dismutase (SOD) in the blood, liver, brain and kidney tissues were determined. Compared with the control group, the activity of SOD in the middle and high dose SO groups decreased significantly (P <0.05), the activity of SOD in the brain tissue increased and the MDA content decreased in each dose group compared with the control group (P <0.05, P <0.01), suggesting that oxidative damage of brain and liver tissue could be induced by 7,8-styrene oxide.