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在第四届国际免疫学会议上,有一位发言人,对十九个专题之一进行总结时指出:免疫学的研究并不象河流那样,一直向前,而恰如海潮一般,进退起伏。这种评价对细胞免疫学来说也许比较真实,但对于免疫球蛋白基因的分子生物学来说,显然是不合适的,该学科自1978年 Tonegawa 等人提出第一个 V 区顺序后,就一直向前发展。然而,在本次会议上,在这一领域内,存在着这样一个征兆,即使算不上后退,至少在研究方向上有着显著的变化。许多一直致力于探求解释抗体分子多样性的分子生物学家,现在已
At the Fourth International Immunological Conference, a spokesman, in summation of one of nineteen thematic issues, pointed out: Immunology research is not going to go forward like a river, but rather to a tidal wave. This assessment may be more realistic for cellular immunology but clearly inappropriate for the molecular biology of immunoglobulin genes since Tonegawa et al. Presented the first V-region sequence in 1978 Has been moving forward. However, at this meeting, there is such a sign in this area that, if not retrogression, there has been notable change in at least the research direction. Many molecular biologists, who have been working to find ways to explain the molecular diversity of antibodies, are now available