类风湿关节炎(rheumatoid arthritis,RA)病人血清中检测出针对变性免疫球蛋白Fc的抗体(即类风湿因子),近年来又发现存在抗Ⅱ型胶原抗体,用Ⅱ型胶原免疫动物可诱发与RA相似的多关节炎动物模型。将抗Ⅱ型胶原抗体输入小鼠体内可将关节炎过继给小鼠,该实验提示Ⅱ型胶原刺激产生的抗Ⅱ型胶原抗体是RA的直接病因之一。胶原是一种糖蛋白,其抗原性是由胶原蛋白的肽链及糖链结构所决定。 1 Ⅱ型胶原与类风湿关节炎 Clague等报告,55％的RA病人血清中可查出Ⅱ型胶原抗体。后来又有资料报道 Antibodies to the degenerative immunoglobulin Fc (ie, rheumatoid factor) have been detected in the serum of patients with rheumatoid arthritis (RA). In recent years, anti-type II collagen antibodies have also been found. Immunization of animals with type II collagen induces RA-like polyarthritis animal model. The introduction of anti-type II collagen antibody into mice can pass arthritis to mice, suggesting that anti-type II collagen antibody produced by type II collagen stimulation is one of the direct causes of RA. Collagen is a glycoprotein whose antigenicity is determined by the collagen and sugar chain structures of collagen. 1 Type II collagen and rheumatoid arthritis Clague and other reports, 55% of patients with RA can be found in the serum type II collagen antibody. Later, there are data reports