基因启动子异常甲基化与肿瘤的发生关系密切 ,它可导致抑癌基因或其它肿瘤相关基因的表达失活。研究显示基因启动子异常甲基化是肿瘤形成过程中的一个早期、频发事件 ,广泛存在于几乎所有种类的人类肿瘤中 ,因此 ,基因启动子区异常甲基化是一个高灵敏度的肿瘤生物标志物 ,检测外周血血清或肿瘤累及器官体液中肿瘤相关基因的甲基化状态将为肿瘤的早期诊断、疗效观察及预后判断提供非常有价值的信息 Aberrant methylation of the gene promoter is closely related to tumorigenesis, which leads to inactivation of the expression of tumor suppressor genes or other tumor-associated genes. Studies have shown that aberrant methylation of the promoter of the gene is an early and frequent event in the process of tumorigenesis and is widespread in almost all kinds of human tumors. Therefore, abnormal methylation of the promoter region of the gene is a highly sensitive tumor organism The detection of methylation status of tumor-associated genes in peripheral blood serum or tumor-associated fluid in the tumor will provide valuable information for the early diagnosis, curative effect and prognosis of the tumor