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以荷瘤小鼠为模型 ,对 α-型重组人肿瘤坏死因子衍生物 rh TNF- α- Da的体内抑瘤作用进行了考察。结果表明 rh TNF- α- Da对 S180 小鼠肉瘤以及荷人肝癌 SMMC772 1和人结肠癌HCT- 8的裸鼠都具有明显的抑制效应 ,且这种作用存在剂量依赖关系 ,预示了该制剂在肿瘤治疗中的潜在应用价值
Tumor-bearing mice were used as models to investigate the anti-tumor effect of α-type recombinant human tumor necrosis factor derivative rh TNF-α-Da in vivo. The results showed that rhTNF-α-Da had a significant inhibitory effect on S180 mouse sarcoma and nude mice bearing human hepatoma SMMC772 1 and human colon cancer HCT-8. This effect was dose-dependent, indicating that the preparation was Potential application value in cancer treatment