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约50%的普通型炎性肌纤维母细胞肿瘤(IMTs)伴ALK基因重排和过表达。近年来,已证明其它激酶的基因融合,如ROS1和PDGFRB,与IMT的发病机制有关。然而这些新出现的基因型是否与IMT的临床病理特征有关仍然未知。本文作者对不同临床表现的IMT大样本进行详细的分子遗传学研究,并分析基因型-表型之间的潜在相关性。
Approximately 50% of common type inflammatory myofibroblastic tumors (IMTs) are associated with ALK gene rearrangement and overexpression. In recent years, gene fusion of other kinases, such as ROS1 and PDGFRB, has been shown to be involved in the pathogenesis of IMT. However, whether these newly emerged genotypes are related to the clinicopathological features of IMT remains unknown. The authors conducted a detailed molecular genetic study of large IMT samples of different clinical manifestations and analyzed the potential association between genotype-phenotype.