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非小细胞肺癌(NSCLC)中,腺癌脑转移的发生率36～57%。鳞癌17～27%。作者对73例局部不能切除的NSCLC 进行预防性颅脑照射(PCI),以评价PCI预防脑转移的效果。男53,女20例,平均年龄58岁.既往均未接受过放疗和化疗。全部病例均经组织学证实,其中腺癌或大细胞癌55例,鳞癌18例。照射前进行体检,全血细胞和血生化检查。骨扫描,胸部X 线、脑、胸、上腹部CT 扫描。血胆红素和血肌酐均<2mg%.先在门诊应用长春花碱(VLB)、丝裂霉素C.入院后用VLB,顺铂各1疗程,休息3周后,开始预防性光子颅脑照射和中子胸部照射.放疗结束4周后再化疗两个疗程。根据治疗方案,化疗两个疗程后对仍
In non-small cell lung cancer (NSCLC), the incidence of adenocarcinoma brain metastases is 36 to 57%. Squamous cell carcinoma 17 to 27%. The authors performed prophylactic cranial irradiation (PCI) in 73 patients with locally unresectable NSCLC to evaluate the effect of PCI in preventing brain metastases. There were 53 males and 20 females, with an average age of 58. No radiotherapy and chemotherapy were received. All cases were confirmed by histology, including 55 cases of adenocarcinoma or large cell carcinoma and 18 cases of squamous cell carcinoma. Physical examination, whole blood cells and blood biochemistry were performed before irradiation. Bone scan, chest X-ray, brain, chest, upper abdomen CT scan. Blood bilirubin and serum creatinine were both <2 mg%. Firstly, vinblastine (VLB) was used in outpatient clinics, mitomycin C was used after admission, and VLB and cisplatin were used for each course of treatment. After 3 weeks rest, preventive photon cranial surgery was started. Brain irradiation and neutron thoracic irradiation. Two cycles of chemotherapy after 4 weeks of radiation therapy. According to the treatment plan, after two courses of chemotherapy