人体转化生长因子α(human transforminggrowth factor-α,TGF-α)是一种含50个氨基酸的肽。其结构与表皮生长因子(EGF)以及牛痘病毒生长因子相关。据认为它是通过与EGF受体结合而发生作用的。无论TGF-α或EGF与本受体的相互反应均可导致受体相关的酪氨酸激酶的活化,并最终引起促细胞分裂反应。为此本文旨在探讨TGF-α与细胞增殖及恶性表型改变的关系。 Human transforming growth factor-α (TGF-α) is a 50 amino acid peptide. Its structure is related to epidermal growth factor (EGF) and vaccinia virus growth factor. It is thought that it works by binding to EGF receptors. Both the interaction of TGF-α or EGF with this receptor can lead to the activation of the receptor-associated tyrosine kinase and eventually induce a mitogenic response. Therefore, the purpose of this study was to investigate the relationship between TGF-α and cell proliferation and malignant phenotypic changes.