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目的：研究沙门菌诱导小鼠产生肿瘤坏死因子。方法：将沙门菌ＳＲ－１１分成两部分，一部分加垫杀死，配成１×１０９ｃｆｕ／鼠．称为死菌；另一部分活菌配成（５～６）×１０３ｃｆｕ／鼠。结果：死菌注射后１小时，对沙门菌抵抗鼠Ａ／Ｊ在血清中产生大量的ＴＮＦ－α；敏感鼠产生低剂量的ＴＮＦ－α；腹水中出现低剂量的ＴＮＦ－α。用活菌刺激小鼠仅在腹水中检出低剂量的ＴＮＦ－α。血清中测不到。结论：死菌刺激小鼠产生大量的ＴＮＦ在血清中。
Objective: To study the production of tumor necrosis factor in mice induced by Salmonella. Methods: Salmonella SR-11 was divided into two parts, one part was added to the mat and killed, and 1×109cfu/rat was formed. Called dead bacteria; another part of live bacteria dubbed (5-6) x 103 cfu/rat. RESULTS: One hour after the injection of the dead bacteria, Salmonella-resistant mice A/J produced a large amount of TNF-α in the serum; sensitive mice produced low-dose TNF-α; and ascites showed low-dose TNF-α. Mice stimulated with live bacteria only detected low doses of TNF-α in ascites. Not detectable in serum. CONCLUSION: Dead bacteria stimulate mice to produce large amounts of TNF in serum.