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目的:探讨胃癌外周血中树突状细胞CD83+表达对预后的影响及意义。方法:选取2010年1月至2011年6月间我科收治的胃癌病人74例进行分析,均为原位癌或仅有局部淋巴结转移,以外周血树突状细胞CD83+为研究对象,以术后生存时间为标准,对病人手术预后进行分析。结果:所选74例病人术后3周测得外周血树突状细胞CD83+表达频数平均值(7.32+1.88)%,以表达频数中位数7.32%为标准将74例病人分为高频组和低频组两组,每组37人。术后总体生存时间108周~413周,平均生存时间(207+227)周,其中高值组平均生存时间(247+121)周,低值组平均生存时间(118+54)周,两组生存时间具有明显差别(P<0.05)。结论:胃癌外周血中树突状细胞CD83+的表达对接受手术病人预后有重要影响,可以作为判断病人预后的参考依据,对预后不良者加以对症及时干预以降低死亡率。
Objective: To investigate the effect of CD83+ expression in the peripheral blood of gastric cancer on the prognosis and its significance. METHODS: Seventy-four cases of gastric cancer patients treated in our department between January 2010 and June 2011 were selected for analysis. They were all carcinomas in situ or only local lymph node metastasis. CD83+ was the study object of peripheral blood dendritic cells. After the survival time as a standard, the patient’s surgical outcomes were analyzed. RESULTS: The mean CD83+ expression frequency of peripheral blood dendritic cells (7.32% and 1.88%) was measured at 3 weeks after operation in 74 patients. The median frequency of expression was 7.32%, and 74 patients were divided into high frequency groups. There were 37 groups in the low frequency group. The overall survival time was 108 weeks to 413 weeks. The average survival time was (207+227) weeks. The average survival time of the high-value group was (247+121) weeks, and the average survival time of the low-value group was (118+54) weeks. There was a significant difference in survival time (P<0.05). Conclusion: The expression of CD83+ in the peripheral blood of gastric cancer has an important influence on the prognosis of patients undergoing surgery. It can be used as a reference for judging the prognosis of patients, and symptomatic interventions can be made to reduce the mortality.