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[目的]观察同步调强放化疗治疗局部晚期鼻咽癌的近期疗效及毒副反应。[方法]2006年4月至2008年4月,80例局部晚期鼻咽癌随机分为同步放化疗组(同步组,n=40)和单纯放疗组(单放组,n=40)。同步组接受调强放疗加顺铂(80mg/m2)治疗,单放组接受单纯调强放疗。[结果]同步组和单放组近期疗效比较无显著性差异(P>0.05)。2年局部控制率同步组为97.5%(39/40),单放组为92.5%(37/40)(P>0.05)。2年无远处转移生存率同步组为95.0%(38/40),单放组为80.0%(32/40)(P<0.05)。同步组Ⅲ/Ⅳ级白细胞下降及恶心、呕吐的发生率明显高于单放组(P<0.05)。[结论]同步调强放化疗对局部晚期鼻咽癌疗效较好,且毒副反应可耐受。
[Objective] To observe the short-term curative effect and side effects of concurrent chemo-radiochemotherapy for locally advanced nasopharyngeal carcinoma. [Methods] From April 2006 to April 2008, 80 patients with locally advanced NPC were randomly divided into concurrent chemoradiotherapy group (n = 40) and radiotherapy alone group (n = 40). Patients in the control group received IMRT plus cisplatin (80 mg / m2), and those in the radiotherapy group received simple IMRT. [Results] There was no significant difference between the two groups in the short term efficacy (P> 0.05). The 2-year local control rate was 97.5% (39/40) in the synchronized group and 92.5% (37/40) in the single-operation group (P> 0.05). No distant metastasis in 2 years was 95.0% (38/40) in the synchronous group and 80.0% (32/40) in the radiotherapy group (P <0.05). The incidences of leukopenia and nausea and vomiting in group Ⅲ / Ⅳ were significantly higher than those in group Ⅲ (P <0.05). [Conclusions] Simultaneous thyromcanectomy and chemoradiotherapy has good effect on local advanced nasopharyngeal carcinoma, and the side effects can be tolerated.