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茶碱是一种广泛用于治疗哮喘和喘息性支气管炎的药物。其生理效应与血药浓度有关,当血药浓度在5μg/ml时有效,在10～20μg/ml显效,大于20μg/ml就可能出现毒性反应。而频繁给药易导致副作用的发生。因此,将茶碱制成缓释制剂口服,既可提供相对稳定的血药浓度,减少毒副反应的发生率,又能维持较久的疗效,减少服药次数。国外已有数种茶碱缓释制剂用于临床,对这些
Theophylline is a widely used drug for the treatment of asthma and asthmatic bronchitis. Its physiological effects and blood concentration, when the plasma concentration of 5μg / ml effective at 10 ~ 20μg / ml markedly, greater than 20μg / ml may be toxic reactions. Frequent administration can easily lead to side effects. Therefore, the theophylline made of sustained-release preparations orally, can provide a relatively stable blood concentration, reduce the incidence of adverse reactions, but also to maintain a longer effect, reduce the number of medication. There are several kinds of theophylline sustained-release preparations abroad for clinical use, to these