非甾体抗炎药(NSAIDs)常见于处方中。这反映了风湿性疾病广泛的发病率,据统计约8％的人群有风湿性症状.各国使用NSAIDs的情况(无论数量或品种)极不相同.NSAIDs的理化性质决定其体内分布,因而这些性质的不同,可导致疗效上的差异.绝大多数NSAIDs具弱酸性,其解离常数(PKa)在3～5之间,一个NSAIDs在特 Non-steroidal anti-inflammatory drugs (NSAIDs) are common in prescriptions. This reflects the widespread incidence of rheumatic diseases, which is estimated to account for about 8% of the population with rheumatic symptoms and very different nationalities (irrespective of quantity or species) of NSAIDs being used. The physical and chemical properties of NSAIDs determine their distribution in vivo and thus these properties Of the difference can lead to differences in the efficacy of the vast majority of NSAIDs with weak acid dissociation constant (PKa) in the 3 to 5, a NSAIDs in special