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目的:探讨基质金属蛋白酶-9(matrix metalloproteinase-9,MMP-9)在大鼠局灶性脑缺血应用尿激酶(urokinase,UK)溶栓引起的再灌注损伤及出血性转化中的作用。方法:将实验动物随机分成UK溶栓组和线栓法缺血再灌注组。分别用免疫组织化学方法分析2组缺血后24h MMP-9的表达。结果:缺血后24h2组均有MMP-9的表达,但是UK溶栓组表达的程度明显高于线栓法缺血再灌注组。结论:UK溶栓法相较于机械法再灌注在MMP-9表达方面有明显的不同,UK溶栓组MMP-9表达明显上调。
Objective: To investigate the role of matrix metalloproteinase-9 (MMP-9) in reperfusion injury and hemorrhagic transformation induced by urokinase (UK) thrombolysis in focal cerebral ischemia in rats. Methods: Experimental animals were randomly divided into UK thrombolysis group and ischemia reperfusion group. Immunohistochemistry was used to analyze the expression of MMP-9 in the two groups 24h after ischemia. Results: The expressions of MMP-9 in the 24h2 group after ischemia were significantly higher than those in the ischemia-reperfusion group. Conclusion: The UK thrombolysis method compared with mechanical reperfusion in the expression of MMP-9 significantly different, the UK thrombolysis group MMP-9 expression was significantly increased.