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The authors report the analysis of HLA- class II allelic heterogeneity in a well characterized multiple sclerosis (MS) Sicilian dataset. Family- based association analysis revealed evidence for excess transmission to affected individuals for alleles HLA- DRB1 1501, DRB1 04, and DQB1 0302. When analyzed as haplotypes, the authors observed excess transmission for the DRB 1 0400- DQB1 0302 haplotype. Sicilian patients share the HLA- DRB1.1501 susceptibility allele with affecteds living in continental Italy, but also display the allelic heterogeneity that characterizes Mediterranean populations.
The authors report the analysis of HLA-class II allelic heterogeneity in a well-characterized multiple sclerosis (MS) Sicilian dataset. Family-based association analysis revealed evidence evidence of excess transmission to affected individuals for alleles HLA-DRB1 1501, DRB1 04, and DQB1 0302 When analyzed as haplotypes, the authors observed excess transmission for the DRB 1 0400- DQB1 0302 haplotype. Sicilian patients share the HLA- DRB1.1501 susceptibility allele with affecteds living in continental Italy, but also display the allelic heterogeneity that characterizes Mediterranean populations.