论文部分内容阅读
目的:观察川芎嗪注射液对家兔肝缺血再灌注损伤(HIRI)的保护作用.方法:制备家兔HIRI模型,30只健康家兔随机分为3组:假手术组10只,损伤组10只,川芎嗪保护组10只.观察肝组织及血中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSHPX)活性、丙二醛(MDA)含量及肝细胞形态学变化.结果:肝缺血再灌注后,川芎嗪保护组与损伤组比较,血浆中SOD明显升高〔缺血45分钟,损伤组(251.00±31.00)KU/L,川芎嗪保护组(341.00±24.00)KU/L,P＜0.01;再灌注45分钟,损伤组(171.00±22.00)KU/L,川芎嗪保护组(331.00±42.00)KU/L,P＜0.01〕;MDA下降非常显著〔再灌注45分钟,损伤组(7.70±0.66)μMOL/L,川芎嗪保护组(6.10±0.64)μMOL/L,P＜0.01〕;肝组织中SOD、GSHPX均明显升高〔SOD损伤组(477.00±89.00)KU/G,川芎嗪保护组(704.00±45.00)KU/G,P＜0.01;GSHPX损伤组(24.20±3.70)KU/G,川芎嗪保护组(33.10±4.80)KU/G,P＜0.01〕,且伴“,”Objective:To explore the protective effects of tetramethylpyrazine injection on hepatic ischemiareperfusion injury (HIRI).Methods:Using a HIRI model ,30 rabbits were randomly divided into 3 groups:shamoperated group ( n =10),injury group ( n =10),and tetramethylpyrazineprotective group ( n =10).Superoxide dismutase (SOD) activity,glutathione peroxidase (GSHPx) activity,malondialdehyde (MDA) content in both serum and hepatic tissue were measured in various groups,and morphological changes in hepatocyte...