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目的探讨鼻咽部炎性肌纤维母细胞肿瘤的临床表现和免疫表型特点。方法对1例发生在鼻咽部的炎症性肌纤维母细胞肿瘤进行光镜观察和免疫组织化学标记,观察项目有Vimentin、SMA、Desmin、S-100蛋白、CD45Ro、CD34、CD3、pan-CK、HMB45、Mac387、NSE、CD68。结果镜下示鼻咽部黏膜下大量增生的呈束状生长的肿瘤性梭形细胞及多角形细胞,可见少量散在神经节样细胞及灶状或片状肿瘤性坏死,炎细胞相对少见。免疫表型,肿瘤细胞胞质Vimentin及SMA呈弥漫强阳性。此例肿瘤呈侵袭性生长过程。结论发生于鼻咽部的炎性肌纤维母细胞肿瘤形态缺乏典型性,加之生长部位隐蔽,手术及活检困难,不易确诊,并且预后不良。
Objective To investigate the clinical features and immunophenotype of nasopharyngeal inflammatory myofibroblastic tumor. Methods One case of inflammatory myofibroblastic tumor in the nasopharynx was observed by light microscopy and immunohistochemistry. The observation items included Vimentin, SMA, Desmin, S-100 protein, CD45Ro, CD34, CD3, HMB45, Mac387, NSE, CD68. Results Microscopically, the tumorous spindle cells and polygonal cells proliferated in the nasopharyngeal mucosa showed a small number of scattered ganglion cells and focal or lamellar neoplastic necrosis. The inflammatory cells were relatively rare. Immunophenotype, tumor cells cytoplasmic Vimentin and SMA were diffusely strong positive. This case of tumor was invasive growth process. Conclusions The tumor morphology of inflammatory myofibroblasts in the nasopharynx is lack of typicality. Combined with hidden parts of growth, difficulty of operation and biopsy, it is not easy to diagnose and the prognosis is poor.