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幽门螺杆菌对人胃粘膜的吸附是实现其感染的第一步。本研究以人上皮细胞株ＨＥｐ—２为材料对幽门螺杆菌吸附上皮细胞的性能进行了探讨，结果显示，幽门螺杆菌ＹＣ—１１Ａ株具有特异吸附于ＨＥｐ—２细胞表面的性能，其吸附能力在与ＨＥｐ—２细胞共孵育３ｈ后达到高峰，吸附率达８１％，此后吸附率虽无显著提高，但单个ＨＥｐ—２细胞吸附的幽门螺杆菌数量却随孵育时间的延长而有明显增加。在大气环境中与在含５％氧气的微氧环境中幽门螺杆菌对ＨＥｐ—２的吸附无显著差异。抗幽门螺杆菌优势抗原单克隆抗体不能有效阻断幽门螺杆菌对ＨＥｐ—２的吸附。
Helicobacter pylori adsorption of human gastric mucosa is the first step in its infection. In this study, the ability of human epithelial cell line HEp-2 to adsorb H. pylori on epithelial cells was investigated. The results showed that H. pylori YC-11A strain has specific adsorption on the surface of HEp-2 cells, and its adsorption capacity After incubation with HEp-2 cells for 3h, the peak was reached, and the adsorption rate reached 81%. After that, although the adsorption rate did not increase significantly, the number of Helicobacter pylori adsorbed by HEp-2 cells increased significantly with the incubation time. There was no significant difference in the adsorption of HEp-2 between H. pylori in the atmosphere and in a micro-oxygen atmosphere containing 5% oxygen. Anti-Helicobacter pylori dominant antigen monoclonal antibody can not effectively block the H. pylori on HEp-2 adsorption.