动物模型是中医药发展的基础。与单纯的疾病模型或证候模型相比,病证结合动物模型更为合理和完善,更能体现中医病证的特点,且更符合临床实际。然而目前的病证结合动物模型存在着诸如造模因素混杂、脱离临床、症状采集及评价方式不完善、客观指标与证候缺乏微观联系、以方测证存在方法学重要缺陷等问题,还需要不断的改进和完善。 Animal model is the basis for the development of Chinese medicine. Compared with simple disease model or syndrome model, animal model combining disease and syndrome is more reasonable and perfect, which can better reflect the characteristics of TCM syndromes and more accord with the clinical practice. However, there are still some problems such as the confounding of modeling factors, the clinical dissociation, the incomplete collection and evaluation of symptoms, the lack of microscopic relationship between objective indicators and syndromes, Continuous improvement and improvement.