众所周知,长期吸入矽尘在肺组织中激起一系列的反应,首先而且主要是肺泡巨噬细胞的吞噬现象.吞噬矽尘后的肺泡巨噬细胞,其溶酶小体与吞噬小体靠笼而结合,因矽尘不能被水解酶分解而破坏了溶酶体膜,导致细胞自身消化而崩解.游离出来的矽尘颗粒又被肺泡巨噬细胞再吞噬,如此反复形成一个不可调节的恶性循环,促进了矽肺病变的发生与发展. As we all know, long-term inhalation of silica in the lung tissue provoked a series of reactions, first and mainly the phagocytosis of alveolar macrophages.A phagocytosed silica dust alveolar macrophages, lysosome and phagosome by the cage The combination of silica dust can not be broken down by lysozyme and lysosomal membrane, leading to cell digestion and disintegration of free silica particles are re-phagocytosis of alveolar macrophages, so repeatedly formed a non-adjustable malignancy Circulation, promote the occurrence and development of silicosis.