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目的探讨酶联免疫斑点试验(ELISPOT)检测结核感染T细胞时斑点数与结核活动程度的相关性。方法回顾性分析结核感染T细胞酶联免疫斑点试验(T-SPOT.TB)检测结果阳性的73例活动性结核病患者和54例非活动性结核患者的斑点数,并研究斑点数与结核活动程度的相关性。结果与非活动性肺结核组相比,活动性肺结核组抗原A和抗原B的斑点数显著上升,差异有统计学意义(P<0.05)。活动性肺结核组中,肺内结核组与肺外结核组抗原A和抗原B斑点数差异无统计学意义(P>0.05)。以抗原A、B斑点数辅助诊断活动性肺结核,ROC曲线下面积分别为0.770和0.856。结论 ELISPOT斑点数与结核活动程度呈正相关,但与结核活动位置无关。
Objective To investigate the correlation between the number of spots and the degree of tuberculosis activity in ELISPOT T cells infected by tuberculosis. Methods The number of spots in 73 active TB patients and 54 inactive TB patients with positive T-SPOT.TB test was retrospectively analyzed. The number of spots and the degree of TB activity Relevance. Results Compared with non-active pulmonary tuberculosis group, the number of spots in active tuberculosis group antigen A and antigen B increased significantly (P <0.05). In the active pulmonary tuberculosis group, there was no significant difference in the number of antigen A and antigen B spots between the pulmonary tuberculosis group and the extrapulmonary tuberculosis group (P> 0.05). The diagnosis of active pulmonary tuberculosis was performed with the aid of antigen A and B spots. The area under the ROC curve was 0.770 and 0.856, respectively. Conclusion There is a positive correlation between the number of ELISPOT spots and the degree of tuberculosis activity, but not with the activity of tuberculosis.