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目的:探讨口服米非司酮进行药物流产与继后妊娠胚胎停育是否相关。方法:选取2003年5月~2010年5月期间于廓坊市妇幼保健中心门诊手术室行人工流产术或清宫术,年龄为22~35岁,孕7~12周的健康妇女3 233例作为研究对象进行前瞻性研究,其中因胚胎停育而行清宫术者896例作为病例组,自愿要求终止妊娠胚胎无任何异常者2 337例为对照组。结果:病例组中有米非司酮服用史者284例,占31.7%,无米非司酮服用史者612例,占68.3%;对照组中有米非司酮服用史者657例,占28.1%,无米非司酮服用史者1 680例,占71.9%,米非司酮服用史与胚胎停育的发生率具有统计学意义(P<0.05)。病例组中米非司酮服用时间与此次妊娠间隔不足两年者73例,占25.7%,间隔时间在两年以上者211例,占74.3%;对照组中米非司酮服用时间与此次妊娠间隔不足两年者129例,占19.6%,间隔时间在两年以上者528例,占80.4%,米非司酮的服用与再次妊娠的间隔时间也与胚胎停育的发生率具有统计学意义(P<0.05)。结论:口服米非司酮会增加继后再次妊娠胚胎停育的风险,尤其是在间隔时间两年之内。
Objective: To investigate whether oral administration of mifepristone induced abortion and subsequent pregnancy embryos are related. Methods: From May 2003 to May 2010, we selected 2333 healthy women aged 22-35 years and 7-12 weeks of pregnancy in the outpatient operating room of Ophthalmology and MCH in Outlet, The study was prospectively studied. Among them, 896 cases who underwent uterine surgery because of the embryo suspension were selected as the case group, and 2 337 cases who voluntarily demanded to terminate the embryo without any abnormality were selected as the control group. Results: There were 284 cases (31.7%) taking mifepristone in the case group, 612 cases without taking mifepristone (68.3%), 657 cases taking mifepristone in the control group 28.1%, no taking history of mifepristone 1 680 cases, accounting for 71.9%, mifepristone taking history and the incidence of embryo suspension was statistically significant (P <0.05). In the case group, 73 cases (25.7%) took mifepristone taking less than two years from the time of the pregnancy, and 211 cases (74.3%) intervening more than two years. The time of taking mifepristone in the control group was In the second trimester of pregnancy, there were 129 cases (19.6%) with interval of more than two years, accounting for 80.4%. The interval between taking mifepristone and re-pregnancy was also related to the rate of embryo stop Significance (P <0.05). CONCLUSIONS: Oral mifepristone increases the risk of subsequent embryo suspension following a second pregnancy, especially within an interval of two years.