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目的:探讨原发性胆囊癌患者手术前后机体自然免疫防御机能和后天获得性免疫机能的对比结果。方法:以15例手术前后的原发性胆囊癌患者及25例正常对照为研究对象,采用微量细胞毒试验-LDH释放法及碱性磷酸酶-抗碱性磷酸酶法(PAP),对自然杀伤细胞(NK)活性和T细胞亚群变化进行了序列测定。结果:原发性胆囊癌患者的NK细胞活性和T细胞亚群中CD3+,CD4+细胞均明显低于正常对照组,而CD8+细胞增高,CD4+/CD8+细胞比值减小,胆囊癌术后患者几种细胞免疫功能指标在原有功能抑制基础上进一步降低,呈现出一个短暂的术后免疫抑制期,继而各项免疫指标均有不同程度的恢复,该抑制期持续时间长短与胆囊癌患者的预后密切相关。结论:胆囊癌根治术可消除这种肿瘤性免疫抑制,提高NK细胞活性和CD3+,CD4+细胞百分值,对原发性胆囊癌患者手术前后定期比较NK细胞活性和T细胞亚群的变化,有助于对患者的预后作出正确评估。
OBJECTIVE: To investigate the comparison of natural immune function and acquired immune function before and after surgery in patients with primary gallbladder cancer. Methods: Twenty-five patients with primary gallbladder carcinoma before and after surgery and 25 normal controls were studied using a micro-cytotoxicity test-LDH release method and alkaline phosphatase-anti-alkaline phosphatase (PAP) method. The killer cell (NK) activity and changes in T cell subsets were sequenced. Results: The activity of NK cells and CD3+ and CD4+ cells in T cell subsets of patients with primary gallbladder carcinoma were significantly lower than those in the normal control group, while CD8+ cells increased and the ratio of CD4+/CD8+ cells decreased. Several patients with postoperative gallbladder cancer The cellular immune function index is further reduced on the basis of the inhibition of the original function, showing a short period of postoperative immunosuppression, and then the various immune indicators have different degrees of recovery. The duration of this inhibition period is closely related to the prognosis of gallbladder cancer patients. . Conclusion: Gallbladder carcinoma surgery can eliminate this tumorigenic immunosuppression, increase the activity of NK cells and the percentage of CD3+ and CD4+ cells, and compare the changes of NK cell activity and T cell subsets before and after surgery in patients with primary gallbladder carcinoma. Helps to make a correct assessment of the patient’s prognosis.