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目的:探讨99mTc-TRODAT-1 SPECT多巴胺转运体(DAT)显像在诊断早期帕金森病(PD)中的意义。方法:对62例早期PD、12例晚期PD及10名正常人进行99mTc-TRODAT-1 SPECT基底节DAT显像,选取纹状体区和小脑为感兴趣区,计算两者的放射性比值,比较3组间该比值的差异,并分析早期PD患者DAT放射性结合率与H&Y分级及UPDRS评分之间的相关性。结果:PD患者基底节99mTc-TRODAT-1摄取率显著降低,早期PD患者病变较重肢体对侧纹状体放射性摄取率较同侧纹状体显著下降。PD患者纹状体区放射性摄取率与PD患者的H&Y分级呈负相关,而与UPDRS Ⅱ、Ⅲ评分无相关性。结论:99mTc-TRODAT-1 SPECT基底节DAT显像可用于临床早期PD的诊断。
Objective: To investigate the significance of 99mTc-TRODAT-1 SPECT dopamine transporter (DAT) imaging in the diagnosis of early Parkinson’s disease (PD). Methods: 99m Tc-TRODAT-1 SPECT basal ganglia DTA imaging was performed on 62 early PD, 12 late PD and 10 normal subjects. The striatal and cerebellum regions of interest were selected to calculate the radioactivity ratio of the two. The differences between the three groups were analyzed and the correlation between DAT radioactive binding rate and H & Y classification and UPDRS score was analyzed in patients with early PD. Results: The uptake rate of 99mTc-TRODAT-1 in basal ganglion of PD patients was significantly lower than that of ipsilateral striatum in patients with early PD. Radiological uptake in the striatum of PD patients was negatively correlated with H & Y classification of PD patients, but not with UPDRS II and III scores. Conclusion: 99mTc-TRODAT-1 SPECT basal ganglia DAT imaging can be used in the diagnosis of early clinical PD.