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目的探讨成人2型糖尿病患者肺组织超微结构的病理特点及临床意义。方法利用透射电镜观察10例2型糖尿病合并肺癌患者远离癌肿组织周围的肺组织活检标本。结果肺Ⅱ型肺泡细胞变小,表面微绒毛消失,嗜锇性板层小体萎缩,失去板层状结构,形成一高电子密度实心小团块;粗面内质网及线粒体均呈囊性扩张,内有透亮物质沉积,常染色质减少、异染色质凝聚;肺泡上皮和血管内皮间基膜弥漫性增厚,呈洋葱皮样改变,周围有蛋白质沉着并与基膜融合。结论肺为糖尿病慢性“攻击”的靶器官。糖尿病所导致的肺组织病理改变有不同于其他肺疾患的自身特点,是肺功能异常的病理基础。
Objective To investigate the pathological features and clinical significance of lung ultrastructure in adults with type 2 diabetes mellitus. Methods Transmission electron microscope was used to observe the biopsy specimens of lung tissue from 10 patients with type 2 diabetes mellitus and lung cancer far away from cancer tissues. Results Pulmonary type Ⅱ alveolar cells became smaller, surface microvilli disappeared, osmiophilic lamellar bodies atrophied, and the lamellar structure was lost, forming a high electron density solid small lumps. The rough endoplasmic reticulum and mitochondria were cystic Expansion, the translucent material deposition, reduce the number of euchromatin, heterochromatin condensation; alveolar epithelial and vascular endothelial membrane thickening of the basement membrane, onion skin-like changes, around the protein deposition and fusion with the basement membrane. Conclusion Lung is the target of chronic “attack” of diabetes. Pathological changes of lung tissue caused by diabetes are different from other lung diseases, their own characteristics, is the pathological basis for abnormal lung function.