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为了研究吡喹酮新制剂(Distocide)的药代动力学,作者进行了以下试验: 1.吡喹酮新制剂(Distocide)和原制剂(Biltricide)在健康者的药代动力学:6名健康者,分成两组,禁食一夜后,按随机交叉设计双盲法顿服Distocide或Biltricide,间歇2周后两组换服药物,剂量均为40mg/kg,服后仍禁食2h。于服药前和服药后24h内定时从静脉采血13次。用高效液相色谱仪测量
In order to study the pharmacokinetics of praziquantel new (Distocide), the authors conducted the following tests: 1. Pharmacokinetics of praziquantel in newborns and healthy people (Biltricide): 6 healthy The subjects were divided into two groups. After a fasting overnight, they were randomized to double-blind crossover with Distocide or Biltricide. After two weeks, the two groups were given medication at a dose of 40 mg / kg and were fasted for 2 hours. Blood samples were obtained from venous blood 13 times before medication and within 24 hours after taking the medicine. Measured by high performance liquid chromatography