急性巨核细胞白血病(AMKL)是临床极少见的急性髓系细胞白血病(AML),国外报道占急性白血病的0.5%~1.2%。其发病呈“双极”趋势,儿童发病均在3岁以内,成人的中位发病年龄为58岁,且多见于慢性粒细胞白血病急性变或继发性白血病。Ph染色体阳性原发性AMKL患者报道罕见,我院收治1例原发性Ph染色体阳性AMKL患者并给予甲磺酸伊马替尼治疗,现报告如下。1病例资料患者,女,35岁,因“上腹疼痛、皮肤出血点 Acute megakaryocyte leukemia (AMKL) is a rare clinical acute myeloid leukemia (AML), foreign reports accounted for 0.5% to 1.2% of acute leukemia. The incidence of ”bipolar“ trend, children are less than 3 years of age, the median age of onset of 58 years old, and more common in patients with acute or secondary chronic myeloid leukemia or secondary leukemia. Ph chromosome positive patients with primary AMKL reported rare cases of our hospital admitted to a primary Ph chromosome positive AMKL patients and given imatinib mesylate treatment are as follows. 1 case data patients, female, 35 years old, because of ”abdominal pain, skin bleeding point