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缺血性疾病是临床上一种严重危害健康,降低患者生活质量,致死、致残率高的疾病,主要包括肢体缺血、糖尿病坏疽、缺血性心肌梗塞及缺血性脑梗塞等。骨髓干细胞(bone marrow-derived stem cells,BMSCs)具有多向分化潜能,已成为缺血性疾病领域的研究热点,通过应用干细胞动员剂动员骨髓干细胞至缺血损伤组织诱使血管新生,改善血流灌注和氧供,修复损伤组织,为缺血性疾病的再血管化治疗提供了新策略。骨髓干细胞动员具有操作简便、安全有效、无创伤以及避免干细胞移植引起的免疫排斥反应的特点,应用骨髓干细胞动员的方法和干预策略具有较好的发展潜力。
Ischemic disease is clinically a serious harm to health, reduce the quality of life of patients, lethal and disabling diseases, including limb ischemia, diabetic gangrene, ischemic myocardial infarction and ischemic infarction. Bone marrow-derived stem cells (BMSCs) have the potential of multi-directional differentiation and have become the research hotspot in the field of ischemic diseases. By using stem cell mobilizing agent to mobilize bone marrow stem cells into ischemic tissue to induce angiogenesis and improve blood flow Perfusion and oxygen supply, repairing damaged tissue provides a new strategy for revascularization of ischemic disease. Bone marrow stem cell mobilization has the characteristics of easy operation, safe and effective, non-invasive and immune rejection caused by stem cell transplantation. It has a good potential for development using methods and intervention strategies of bone marrow stem cell mobilization.