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为观察小剂量肝素在慢性肾功能不全(CRI)氮质血症期的治疗作用及不良反应,对34例早期CRI进行了治疗前后的观察。结果显示:①观察组治疗前后比较血肌酐、尿素、24h尿蛋白排出量(Upro)明显下降,内生肌酐清除率明显升高(P<0.05)。②观察组治疗前后比较部分凝血活酶、高密度脂蛋白、载脂蛋白(Apo)A、ApoA/ApoB明显升高,纤维蛋白原、总胆固醇、甘油三酯、低密度脂蛋白明显下降(P<0.05)。③无明显副作用。结论:小剂量肝素用于治疗CRI可改善肾功能,但应加强监测,以策安全。
To observe the therapeutic effects and side effects of low dose heparin in chronic azepam (CRI) azotemia, 34 patients with early CRI were observed before and after treatment. The results showed that: (1) Compared with serum creatinine and urea, the urinary protein excretion (Upro) in observation group decreased significantly before and after treatment, and the creatinine clearance rate was significantly increased (P <0.05). ② The levels of some thromboplastin, high density lipoprotein, apolipoprotein A and ApoA / ApoB in the observation group before and after treatment were significantly increased, and the levels of fibrinogen, total cholesterol, triglyceride and low density lipoprotein were significantly decreased (P <0.05). ③ no obvious side effects. Conclusion: Small dose of heparin for the treatment of CRI can improve renal function, but should be strengthened to monitor safety.