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口服甘露醇治疗内科疾病报道颇多。但是，包括经典在内的几乎全部文献资料都认为口服不吸收。为了提供治疗学依据，指导临床用药，本文报道对８名健康自愿受试者进行了口服药代动力学研究，血药浓度时间数据采用夏文江氏（ＭＣＰＫＰ）药代动力学程序，计算机自动拟合，所得数据符合开放性二室模型（一级吸收），分布半衰期（ｔ１／２α）为０．６８小时，消除半衰期（ｔ１／２β）为３．６４小时，最高血药浓度（Ｃｍａｘ）为４３１μｇ／ｍｌ，肾清除率（Ｋｅｌ）为０．４９０小时，达峰时间（ＴＰ）为１．０小时。本实验结果提供了药效学依据，所供参数对临床制订给药方案具有重要参考价值：计算结果还显示了个体差异明显，提示了药物剂型或给药途径还值得进一步研究。
Mannitol oral treatment of medical diseases reported a lot. However, almost all of the literature, including the classic, considers orally non-absorbable. In order to provide a basis for the treatment of the disease and to guide the clinical use of drugs, oral pharmacokinetics studies were conducted on eight healthy volunteers. The pharmacokinetics of MCPKP was used to determine the plasma concentration time. The data obtained were in accordance with the open two-compartment model (primary absorption). The distribution half-life (t1 / 2α) was 0.68 hours and the elimination half-life was 3.64 hours. The maximum plasma concentration (Cmax) 431 μg / ml, renal clearance (Kel) was 0.490 hours and peak time (TP) was 1.0 hour. The experimental results provide a basis for pharmacodynamics, the parameters for the clinical formulation of the program has an important reference value: the results also showed significant individual differences, suggesting that the drug formulation or route of administration is still worth further study.