目的：研究重组人粒细胞巨噬细胞集落刺激因子（ｒｈＧＭＣＳＦ）在恒河猴体内的药物动力学．方法：用酶连接免疫吸附测定法检测血浆中ｒｈＧＭＣＳＦ的含量．结果：ｉｖｒｈＧＭＣＳＦ后血药浓度时间曲线符合三房室模型．第１，２和３相的Ｔ１２分别为００５－００７ｈ，０１４－０５８ｈ和１４－４１ｈ．ＡＵＣ随剂量成比例增加．ｉｖ高剂量和低剂量的Ｃｌ和Ｋ１０都相似．ｓｃｒｈＧＭＣＳＦ后血药浓度的峰值为０９３±０１６μｇ·Ｌ－１，达峰时间为２６５±０１４ｈ，生物利用度为０６１．结论：恒河猴ｒｈＧＭＣＳＦ药物动力学数据为临床试验提供有用参考． Objective: To study the pharmacokinetics of recombinant human granulocyte-macrophage colony-stimulating factor (rhGMCSF) in rhesus monkeys. Methods: Enzyme linked immunosorbent assay was used to detect the content of rhGMCSF in plasma. Results: The plasma concentration time curve of ivrhGM-CSF was in accordance with the three-compartment model. The T12 of phase 1, 2 and 3 were 005-007h, 014-058h and 14-41h, respectively. AUC increases proportionally with dose. iv Both high dose and low dose of Cl and K10 are similar. The peak plasma concentration of scrhGM-CSF was 093 ± 016 μg · L-1, the peak time was 265 ± 014 h, the bioavailability was 061. Conclusion: Rhesus monkey rhGM  CSF pharmacokinetic data for clinical trials provide a useful reference.