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鉴于作者等(1983)曾报告乙胺嘧啶对早期怀孕可能有致畸胎的作用,因而对怀孕期使用乙胺嘧啶复方(包括乙胺嘧啶合并二苯砜或周效磺胺)提出仅在如下二种情况下进行。一,在有恶性疟抗药性发生的地区,使用乙胺嘧啶复方作群众性预防疟疾时,为了保护母亲们的健康与安全,如在无适用的替代药,仍可服用。二、到东南亚或类似地区旅行的妇女,可在短期内服乙胺嘧啶复方用以预防疟疾,但同时要进行避孕。作者特别强调,乙胺嘧啶可能对早期怀孕有致畸胎的作用必
Since the authors (1983) have reported that pyrimethamine may have a teratogenic effect on early pregnancy, the use of pyrimethamine in pregnancy (including pyrimethamine with diphenyl sulfone or psoriasis) was proposed only in the following two Case. First, in the area where there is resistance to falciparum malaria, when pyrimethamine is used for mass prevention of malaria, in order to protect the health and safety of mothers, if no alternative medicine is available, they can still be taken. Second, women who travel to Southeast Asia or similar areas may be given pyrimethazine for the prevention of malaria in the short term, but contraception should also be carried out at the same time. In particular, the authors emphasize that pyrimethamine may have teratogenic effects on early pregnancies