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丙型肝炎病毒(HCV)血清分型以快速、简便优于多聚酶链反应(PCR)分型法。本文作者使用核心或非结构4(NS4)区衍生的型特异性抗原肽考查了两种HCV血清分型法的灵敏度和特异性,并且与核心区型特异引物分子分型的结果进行比较,虽然两种血清分型和基因分型之间有良好的一致性,但是前者的灵敏度较低。作者研究75例抗HCV阳性患者,38例患者可能为非肠道感染;29例患者肝组织学状况为:2例正常,4例有轻微肝病变,7例有慢性特续性肝炎,1例有慢性小叶性肝炎,10例有轻度及3例有中度慢性活动性肝炎,2
Hepatitis C virus (HCV) serotyping is faster and easier than polymerase chain reaction (PCR) typing. The authors examined the sensitivity and specificity of the two HCV serotyping methods using type-specific antigenic peptides derived from core or non-structural 4 (NS4) regions and compared them with the results of molecular typing of core-region-specific primers There was good agreement between the two serotypes and genotypes, but the former was less sensitive. The authors studied 75 anti-HCV positive patients, 38 patients may be non-intestinal infections; liver histology in 29 patients were: 2 cases of normal, 4 cases of mild liver disease, 7 cases of chronic severe hepatitis, 1 case There are chronic lobular hepatitis, 10 cases were mild and 3 cases of moderate chronic active hepatitis, 2