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目的:探讨正常孕妇各孕期血清脑利钠肽(BNP)值的变化及其与子痫前期发病的关系。方法:共检测199例从孕早期至分娩前期孕妇血清BNP值,统计分析子痫前期孕妇与正常孕妇各孕期外周血清BNP值中位数的差异。结果:正常孕妇各孕期血清BNP中位数保持相对稳定,分别为17.3 pg/mL、16.9 pg/mL、15.8 pg/mL和18.6 pg/mL,正常孕妇,轻度子痫前期和重度子痫前期孕妇血清BNP值为17.1 pg/mL、22.7 pg/mL和118 pg/mL,重度子痫前期患者血清BNP值与正常孕妇及轻度子痫前期孕妇血清BNP差异有统计学意义(P<0.001)。结论:正常孕妇血清BNP浓度在各孕期保持相对稳定;子痫前期患者血清BNP浓度显著高于同孕周正常孕妇,BNP与子痫前期发病存在相关关系。
Objective: To investigate the changes of serum brain natriuretic peptide (BNP) in pregnant women during pregnancy and its relationship with preeclampsia. Methods: A total of 199 serum BNP levels in pregnant women from the first trimester to the first trimester of pregnancy were detected. The median of BNP in peripheral blood serum of pregnant women and normal pregnant women was statistically analyzed. Results: The median of serum BNP in normal pregnant women remained relatively stable at 17.3, 16.9, 15.8 and 18.6 pg / mL, respectively. The positive pregnant women, mild preeclampsia and severe preeclampsia Serum BNP levels in pregnant women were 17.1 pg / mL, 22.7 pg / mL and 118 pg / mL, respectively. The serum BNP levels in severe preeclampsia patients were significantly different from those in normal pregnant women and those with mild preeclampsia (P <0.001) . Conclusions: Serum BNP levels in normal pregnant women remain relatively stable during each pregnancy. Serum BNP levels in preeclampsia patients are significantly higher than those in normal pregnant women, and there is a relationship between BNP and preeclampsia.